Figure 4. Vh mutation frequencies, Vh family and Jh gene usage of the different B-cell subsets.
(A) Vh mutation frequencies were estimated by comparison with the IMGT database. Mutation frequencies are calculated based on the average mutation value obtained for each clone. The mutation frequency observed for the naive B cell pool (0.7 %) is represented by a dotted line, and is taken as an estimate of the contribution of sequencing errors. Vh family (B) and Jh gene (C) usage.