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. Author manuscript; available in PMC: 2015 Dec 18.
Published in final edited form as: Nature. 2015 May 18;522(7556):349–353. doi: 10.1038/nature14407

Figure 1. Met deficiency inhibits neutrophil recruitment to tumour and metastatic site.

Figure 1

a-g, LLC tumour growth (a), weight (b), lung macrometastases (c), metastatic area (d), representative images of H&E-stained lung sections (e,f), metastatic index (g) in WT→WT and KO→WT chimeras. Data combine 3 independent experiments; total mice: WT→WT=23, KO→WT=26. h-m, Neutrophil quantification and representative images on Ly6G-stained LLC tumour sections (h-j) or on lung sections from tumour-free and tumour-bearing mice (k) represented in (l,m). Data in (h) are representative of 4 independent experiments (6 mice/condition per experiment). Data in (k) combine 3 independent experiments; total mice: Tumour-free=10/condition, Tumour-bearing=15/condition. n-q, LLC tumour growth (n), tumour weight (o), lung macrometastases (p), TAN quantification (q) in WT→WT and KO→WT control chimeras (Mrp8:Empty) or upon neutrophil-specific Met reconstitution (Mrp8:Met). Data combine 2 independent experiments; total mice=10/condition. r-u, LLC tumour growth (r), tumour weight (s), lung macrometastases (t), TAN quantification (u) upon neutrophil-specific Met deletion (Mrp8;Metlox/lox) and controls (Mrp8;Metwt/wt). Data combine 2 independent experiments; total mice=13/condition. *, P<0.05. Scale bars: 100 μm (e,f), 50 μm (i,j,l,m). Graphs show mean ± s.e.m..