Extended Data Table 1. Blood count in Tie2;Met^wt/wt or Tie2;Met^lox/lox tumour free mice.

The values show the hematological parameters (mean ± s.e.m.) in tumour free Tie2;Met^wt/wt and Tie2;Met^lox/lox mice. Data combine 2 independent experiments; total n=10/condition. Abbreviations: white blood cell (WBC), neutrophil (NEU), lymphocyte (LYM), monocyte (MON), eosinophil (EOS), basophil (BAS), red blood cell (RBC), hematocrit (HCT), mean cell hemoglobin concentration (MCHC), platelet (PLT).

Tumour free	Tie2;Metwt/wt	Tie2;Metlox/lox
WBC (k/μl)	5.68±1.44	5.55±1.29
NEU (%)	23.03±5.45	29.67±7.88
LYM (%)	69.72±6.46	72.03±4.89
MON (%)	1.24±0.37	2.86±1.15
EOS (%)	0.12±0.05	0.17±0.12
BAS (%)	3.38±1.32	4.47±2.1
RBC (M/μL)	5.21±1.91	4.89±1.52
HCT (%)	71.3±3.43	60.2±13.38
MCHC (g/dl)	15.83±2.65	18.3±0.26
PLT (K/μL)	439.73±26.64	508±55.79