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Propellor tip FBXW7 mutations are less likely than other mutations to have a ‘second hit’. Samples were assigned as having second hits if they were ‘homozygous’ in the COSMIC zygosity field (assumed to have LOH) or if they had two mutations in the COSMIC list. Heterozygotes were listed as such in the COSMIC zygosity field
| No second hit | Second hit | Total | |
|---|---|---|---|
| Propellor tip (codons 465, 479, 505) missense mutation | 50 | 7 | 57 |
| Other mutation | 38 | 20 | 58 |
| Total | 88 | 27 | 115 |
