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The combined set of missense FBXW7 mutations has a lower frequency of LOH than does the combined set of truncating mutations. Second hits were assigned as in Table 1. Six compound heterozygous samples with one truncating and one missense mutation were assigned as half-data points to each of the two ‘second hit’ categories
| No second hit | Second hit | Total | |
|---|---|---|---|
| Missense mutation | 68 | 12 | 80 |
| Protein-truncating mutation | 16 | 9 | 25 |
| Total | 84 | 21 | 105 |
