Fig. 7.

Body weights. During dosing (a), all groups had comparable weights on post- natal day (PD) 11, but by PD 12 all treated groups with the exception of the Cit5+Sal group weighed less than Sal+Sal. Throughout the remainder of dosing (PD 13–20), all drug-treated groups had significantly lower body weights compared to Sal+Sal. (b) Body weights on PD 21 and PD 28 remained significantly decreased by the drug treatments with all groups weighing less than Sal+Sal. Body weights taken from PD 35–98 were significantly affected by drug treatment with all groups that received Cit alone or in combination with 3,4-methylenedioxymethamphetamine (MDMA) weighing less than Sal+Sal. (c) Body weight at PD 56 just prior to the start of behavioural testing. (d) Body weight at PD 98 after completion of behavioural testing. (a): * p<0.05, all groups were different except Cit5+Sal vs. Sal+Sal; *** p<0.001, all drug treated groups compared to Sal+Sal. (b, c, d): ** p<0.01, compared to Sal+Sal; *** p<0.001 compared to Sal+Sal; n=16–27 per group (males) from 27 different litters; not more than one rat per group from any one litter was used to control for litter effects. Cit5, 5 mg/kg citalopram; Cit7.5, 7.5 mg/kg citalopram; Sal, saline.