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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Nanomedicine (Lond). 2015 Feb;10(3):447–463. doi: 10.2217/nnm.14.179

Figure 6. Relationship between phagocytosis in monocytes/dendritic cells from blood and clearance of PEGylated liposomal agents in mice, rats, dogs and patients.

Figure 6

The mean values for three species are represented by individual symbols, with diamonds as PLD, squares as S-CKD602 and triangles as SPI-077. The species data are in vertical columns from left to right: rats, mice, dogs and patients. The best fit line for each group is represented by the solid lines. Across species, a positive association was observed between cell function and CL of PEGylated liposomes.

CL: Clearance; MFI: Mean fluorescent intensity; MPS: Mononuclear phagocyte system; PK: Pharmacokinetics; PLD: PEGylated liposomal doxorubicin; R2: Coefficient of determination.

Adapted with permission from [44].