The mean values for three species are represented by individual symbols, with diamonds as PLD, squares as S-CKD602 and triangles as SPI-077. The species data are in vertical columns from left to right: rats, mice, dogs and patients. The best fit line for each group is represented by the solid lines. Across species, a positive association was observed between cell function and CL of PEGylated liposomes.
CL: Clearance; MFI: Mean fluorescent intensity; MPS: Mononuclear phagocyte system; PK: Pharmacokinetics; PLD: PEGylated liposomal doxorubicin; R2: Coefficient of determination.
Adapted with permission from [44].