Table 2.

	Grade 0	Grade 1	Grade 2	Grade 3
Collagen	Collagen arranged in tightly cohesive well demarcated bundles with a smooth dense bright homogeneous polarization pattern with normal crimping	Diminished fiber polarization: separation of individual fibers with maintenance of demarcated bundles	Bundle changes: separation of fibers with loss of demarcation of bundles giving rise to expansion of the tissue overall and clear loss of normal polarization pattern	Marked separation of fibers with complete loss of architecture
	Wt, KO = t = 0		Wt = 72h	KO = 72h