Table 5.
Differentially expressed genes in lightly (HEM-L) vs. darkly (HEM-D) pigmented melanocytes.
| Gene Name (Gene ID) | Relative expression in HEM-L vs. HEM-D | Fold Change | FDR p-value |
|---|---|---|---|
| apolipoprotein C-I (APOC1) | Up-regulated | 13 | 3.81 × 10−3 |
| apolipoprotein C-II (APOC2) | Up-regulated | 117 | 2.74 × 10−7 |
| family with sequence similarity 171, member A1 (FAM171A1) | Up-regulated | 12 | 1.81 × 10−2 |
| glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) | Up-regulated | 8 | 1.63 × 10−2 |
| leucine rich repeat containing 61 (LRRC61) | Up-regulated | 20 | 2.23 × 10−2 |
| leucine rich repeat neuronal 1 (LRRN1) | Up-regulated | 47 | 1.12 × 10−2 |
| protein tyrosine phosphatase N, polypeptide 2 (PTPRN2) | Up-regulated | 24 | 3.23 × 10−2 |
| sarcoglycan, delta (SGCD) | Up-regulated | 15 | 2.74 × 10−2 |
| solute carrier family 45, member 2 (SLC45A2) | Up-regulated | 8 | 4.22 × 10−2 |
| tudor domain containing 12 (TDRD12) | Up-regulated | 27 | 2.69 × 10−3 |
| zinc finger protein 423 (ZNF423) | Up-regulated | 17 | 2.71 × 10−2 |
| claudin 1 (CLDN1) | Down-regulated | 10 | 1.43 × 10−2 |
| CXXC finger protein 4 (CXXC4) | Down-regulated | 19 | 1.59 × 10−2 |
| kinase insert domain receptor (KDR) | Down-regulated | 8 | 2.21 × 10−2 |
| myosin VIIB (MYO7B) | Down-regulated | 25 | 3.81 × 10−2 |
| protein tyrosine phosphatase, receptor type, O (PTPRO) | Down-regulated | 18 | 4.88 × 10−2 |
The number of reads that aligned to the identified genes in the HEM-L and HEM-D libraries were analyzed with the edgeR software to detect significant differences (FDR p-value < 0.05). The only pigmentation-associated gene differentially regulated (SLC45A2) is shown in bold.