Table 7.
Expression of cell signaling isoforms in HEM-L and HEM-D.
| A. Isoforms only expressed in HEM-D | |||
|---|---|---|---|
| Gene Name (Gene ID) | Accession Number | Gene Family | Transcript Variant |
| 5-hydroxytryptamine (serotonin) receptor 7 (HTR7) | NM_019859.3 | GPCR | Variant D Canonical sequence |
| frizzled class receptor 6 (FZD6) | NM_001164616.1 | GPCR | Variant 3 32aa missing |
| activin A receptor, type IC (ACVR1C) | NM_145259.2 | RK | Variant 1 Canonical sequence |
| histone linker H1 domain, spermatid-specific 1 (HILS1) | NR_024192.1 | TF | Variant 2 Non-coding |
| zinc finger protein 83 (ZNF83) | NM_001105550.1 | TF | Variant 3 Different 5’UTR |
| nuclear receptor subfamily 6, group A, member 1 (NR6A1) | NM_001489.4 | NR | Variant 2 5aa missing |
| B. Isoforms only expressed in HEM-L | |||
|---|---|---|---|
| Gene Name (Gene ID) | Accession Number | Gene Family | Transcript Variant |
| histamine receptor H4 (HRH4) | NM_001143828.1 | GPCR | Variant 2 88aa missing |
| regulator of G-protein signaling 3 (RGS3) | NM_001282922.1 | GAP | Variant 2 398aa missing |
| postmeiotic segregation increased 1(PMS1) | NM_001128143.1 | TF | Variant 2 39aa missing |
| ets variant 7 (ETV7) | NM_001207038.1 | TF | Variant 5 77aa missing |
| T-box 3 (TBX3) | NM_016569.3 | TF | Variant 2 Canonical sequence |
| hes family bHLH transcription factor 6 (HES6) | NM_018645.4 | TF | Variant 1 Canonical sequence |
| cut-like homeobox 1 (CUX1) | NM_001202546.1 | TF | Variant 7 39aa missing |
| myoneurin (MYNN) | NM_001185119.1 | TF | Variant 3 29aa missing |
| WD repeat & HMG-box DNA binding protein 1 (WDHD1) | NM_001008396.2 | TF | Variant 2 123aa missing |
| zinc finger protein (ZNF200) | NM_198087.2 | TF | Variant 3 1aa missing |
| zinc finger protein (ZNF662) | NM_207404.3 | TF | Variant 1 Canonical sequence |
| zinc finger protein (ZNF674) | NM_001039891.2 | TF | Variant 1 Canonical sequence |
| zinc finger protein 75D (ZNF75D) | NM_001185063.2 | TF | Variant 2 95aa missing |
| zinc finger protein (ZNF805) | NM_001145078.1 | TF | Variant 2 133aa missing |
Transcript isoforms from cell signaling gene families expressed exclusively in lightly pigmented (A) or darkly pigmented (B) HEMs Isoforms below expression threshold (FPKM < 0.1) and with high variability (SEM > 35% of its average FPKM) were excluded. Abbreviations: GPCR, G protein-coupled receptor; RK, receptor kinase; GAP, GTPase-accelerating protein; TF, transcription factor; NR, Nuclear receptor.