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. 2015 Oct 5;16:745. doi: 10.1186/s12864-015-1944-z

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© Zhang et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Assessment of inferred direct interactions using the genetic interaction profiles. Interactions are ranked by scores calculated using corresponding methods. Performance of all methods is measured by plotting the number of top-ranking inferred direct interactions of a method against the number of these interactions which also have high genetic profile similarities. Functional similarity of proteins is measured by Pearson’s correlation between their genetic interaction profiles, and protein pairs with functional similarities ≥0.2 are used to construct the genetic interaction reference set. a Collins dataset, b Friedel dataset