Table 5.
Pharmacokinetic Parameters of the HPMA Copolymer Conjugates Containing D-Asp8 or Alendronate (24 h) Based on Noncompartment Model
| conjugate | AUC (% dose/(mL h)) | T1/2(γz) (h) | CL (mL/h) | MRT (h) | Vss (mL) |
|---|---|---|---|---|---|
| C-L1 (27 kDa) | 235.3 ± 24.2 | 9.3 ± 1.1 | 0.359 ± 0.03 | 6.0 ± 0.7 | 2.6 ± 0.33 |
| d-Asp8 conjugate (24 kDa) | 3.1 | 5.3 | 31.0 | 4.0 | 130 |
| C-Lh (46 kDa) | 446.9 ± 50.1 | 12.9 ± 1.3 | 0.165 ± 0.02 | 7.3 ± 0.8 | 1.6 ± 0.21 |
| d-Asp8 conjugate (46 kDa) | 63.5 | 6.4 | 1.467 | 4.4 | 6.9 |
| C-Hl (126 kDa) | 568.2 ± 57.3 | 18.5 ± 1.9 | 0.105 ± 0.01 | 8.6 ± 0.9 | 1.5 ± 0.17 |
| d-Asp8 conjugate (96 kDa) | 405.6 | 15.3 | 0.160 | 8.4 | 2.1 |