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. Author manuscript; available in PMC: 2015 Oct 6.
Published in final edited form as: Immunol Rev. 2013 Nov;256(1):95–106. doi: 10.1111/imr.12116

Fig. 1. Mechanism of T-cell microtubule-organizing center (MTOC) reorientation to the immunological synapse (IS).

Fig. 1

Localized diacylglycerol accumulation induces the ordered recruitment of protein kinase C (PKC) isozymes. This drives the recruitment of dynein to the IS and the redistribution of non-muscle myosin II (NMII) to the sides and rear of the cell. Dynein and NMII then collaborate to move the MTOC. The process is schematized to the left, with a pathway diagram to the right. In the pathway diagram, solid arrows denote direct connections, and dotted arrows denote either indirect or multistep connections.