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. Author manuscript; available in PMC: 2015 Oct 6.
Published in final edited form as: J Med Chem. 2013 May 23;56(11):4786–4797. doi: 10.1021/jm4005048

Table 2.

IC50 Values and Selectivity of Various Cycloalkyl Analogues

graphic file with name nihms720911t22.jpg
Compound
#		 R1 Cav1.3
IC50(µM)		 Cav1.2
IC50(µM)		 Selectivity
61 graphic file with name nihms720911t23.jpg 32.7 ±11 33.4 ±1.8 1.1
62 graphic file with name nihms720911t24.jpg 39.3 ±6.8 29.1 ±1.3 0.7
63 graphic file with name nihms720911t25.jpg 11.9 ±0.4 10.6 ±1.0 0.9
64 graphic file with name nihms720911t26.jpg 50.3 ±15 33.9 ±0.2 0.7
65 graphic file with name nihms720911t27.jpg >100 >100
66 graphic file with name nihms720911t28.jpg 10.4 ±1.3 8.5 ±0.9 0.8
67 graphic file with name nihms720911t29.jpg >100 >100
68 graphic file with name nihms720911t30.jpg 9.7 ±0.1 6.7 ±0.1 0.7
69 graphic file with name nihms720911t31.jpg >100 >100
70 graphic file with name nihms720911t32.jpg 30.3 ±1.8 34.6 ±4.3 1.1
71 graphic file with name nihms720911t33.jpg >100 48.1 ±5.3
72 graphic file with name nihms720911t34.jpg 38.6 ±1.6 23.4 ±0.5 0.6
73 graphic file with name nihms720911t35.jpg 12.0 ±0.9 12.6 ±0.4 1.0
74 graphic file with name nihms720911t36.jpg 13.7 ±2.0 12.9 ±0.3 0.9
75 graphic file with name nihms720911t37.jpg 11.7 ±3.2 25.2 ±3.7 2.2
36 graphic file with name nihms720911t38.jpg 3.09 ±0.9 13.2 ±9.7 4.3
76 graphic file with name nihms720911t39.jpg 10.8 ±1.4 10.0 ±0.1 0.9