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IC50 Values and Selectivities of Various Norbornyl Analogues
 | |||||
|---|---|---|---|---|---|
| Compound # |
R1 | R2 | Cav1.3 IC50(µM) |
Cav1.2 IC50(µM) |
Selectivity |
| 100 |  |
 |
3.4 ±0.2 | 8.0 ±1.0 | 2.4 |
| 101 |  |
 |
3.6 ±0.3 | 4.1 ±0.6 | 1.1 |
| 102 |  |
 |
2.4 ±0.3 | 5.1 ±1.1 | 2.1 |
| 103 |  |
 |
2.3 ±0.4 | 2.8 ±0.3 | 1.2 |
| 104 |  |
 |
1.8 ±0.7 | 3.8 ±0.4 | 2.2 |
| 105 |  |
 |
2.7 ±0.2 | 4.6 ±1.7 | 1.7 |
| 106 |  |
 |
2.4 ±0.2 | 100 ±6.3 | 40.8 |
| 107 |  |
 |
3.0 ±0.5 | >100 | >33.0 |
| 108 |  |
 |
2.1 ±0.1 | 76.6 ±.8.0 | 36.0 |
| 109 |  |
 |
2.7 ±0.2 | 3.1 ±0.2 | 1.2 |
