Table 3. Top 10 hub genes in yellow module.
| Rank | Gene | Locus | Product / function | Disease associations |
|---|---|---|---|---|
| 1 | CLCN6 | 1p36 | Voltage-gated chloride channel proteins | Blood pressure |
| 2 | SAG | 2q37 | Cellular responses in retina and pineal gland | Oguchi disease |
| 3 | AOC2 | 17q21 | Copper binding | Ocular diseases |
| 4 | LILRA6 | 19q13 | Leukocyte immunoglobulin-like receptor | - |
| 5 | PCDHA5 | 5q31 | Neural cell adhesion proteins | - |
| 6 | LYPD6 | 2q23 | Disulfide-bonding proteins | - |
| 7 | LHX6 | 9q33 | Development of neural and lymphoid cells | Lung cancer, cervical cancer |
| 8 | LOC390531 | 15q11 | Non-functional | - |
| 9 | CISH | 3p21 | Regulation of cytokine-signaling | Infectious diseases |
| 10 | HNMT | 2q22 | Metabolization of histamine | Parkinson’s disease |