Fig. 5.

Effect of BQ788 and Cav-1 peptide on SE-induced ROCK1 expression at 3 days after SE. a Western blot images of ROCK1 in the hippocampus. BQ-788 infusion attenuates up-regulation of ROCK1 expression induced by SE. b Quantitative values (mean ± S.E.M) of ROCK1 expression level in the hippocampus (n = 10 per each group). Significant differences from vehicle, *p < 0.05. c-e Representative photographs of ROCK1 and NeuN in the CA1 pyramidal cells. As compared to non-SE, ROCK1 expression is increased and NeuN expression is decreased at three days after SE. BQ788 attenuates up-regulation of ROCK1 expression and down-regulation of NeuN expression by SE. Bar = 50 μm. f Quantitative values (mean ± S.E.M) of ROCK1 and NeuN in the hippocampus, based on immunofluorescent study (n = 10 per each group). Significant differences from vehicle, *p < 0.05