Fig 6. Histologic scores correlate with MR-derived necrotic volumes and post-irradiation time.

A. Correlation between MR-derived necrotic volumes and histological scores. MR-derived volumes, mean ± SD (n = 30, 37, 27, and 53 for Grade 0, 1, 2, and 3, respectively), of radiation necrosis vs. histological score for irradiated mice, independent of specific radiation dose (45–60 Gy) and treatment schedules. B. Correlation between histological scores and time post irradiation. Box-and-whisker plots of the histological scores for mice receiving 50/60-Gy of radiation, at 4, 8, and 13 weeks post irradiation. The 25th-75th percentiles are blocked by the box, the band inside the box is the mean, and the whiskers mark the maximum and minimum values.