Table 1.
Baseline characteristics in 530 children with or without growth failure before celiac disease diagnosis
| Growth failure n = 182 | Normal growth n = 348 | ||||
|---|---|---|---|---|---|
| n a | Median (Q1, Q3) | n a | Median (Q1, Q3) | P value | |
| Age at diagnosis, yr | 182 | 6.3 (2.5, 11.7) | 348 | 8.0 (5.0, 12.0) | <0.001 |
| Age of menarche, yr | 23 | 13.0 (12.0, 13.0) | 45 | 12.0 (12.0, 13.0) | 0.146 |
| Height, SDb | 45 | −0.5 (−1.2, 0.4) | 134 | 0.2 (−0.5, 0.9) | 0.004 |
| Weight, SD | 34 | −1.1 (−1.9, −0.2) | 114 | −0.3 (−0.9, 0.6) | 0.003 |
| Weight/height percentage | 65 | −9.0 (−15.0, −1.0) | 163 | 0.1 (−8.0, 9.0) | <0.001 |
| Body mass index, kg/m2 | 68 | 15.7 (14.3, 16.6) | 155 | 16.6 (15.1, 19.2) | <0.001 |
| EmA, titer | 81 | 500 (200, 2000) | 205 | 200 (100, 1000) | <0.001 |
| TG2ab, U/lc | 98 | 120.0 (71.3, 120.0) | 253 | 120.0 (39.0, 120.0) | 0.035 |
| Hemoglobin, g/l | 129 | 122 (115, 128) | 248 | 126 (115, 133) | 0.016 |
| MCV, fl | 96 | 81 (75, 83) | 207 | 81 (76, 83) | 0.662 |
| Alkaline phosphatase, U/l | 42 | 309 (148, 511) | 79 | 231 (184, 322) | 0.180 |
| ALT, U/l | 34 | 24 (18, 32) | 83 | 20 (16, 25) | 0.035 |
| Total iron, μmol/l | 33 | 10.0 (6.6, 15.0) | 58 | 12.5 (9.3, 17.8) | 0.304 |
| Albumin, g/l | 18 | 37 (34, 41) | 50 | 39 (37, 41) | 0.252 |
| TSH, mU/l | 43 | 2.8 (2.2, 3.7) | 58 | 2.4 (1.6, 3.1) | 0.013 |
| Thyroxin, pmol/l | 31 | 14.4 (12.6, 16.9) | 25 | 14.8 (12.9, 16.3) | 0.817 |
Q1, Q3, lower and upper quartiles; SD, standard deviation; EmA, endomysial antibodies; TG2ab, transglutaminase 2 antibodies; MCV, mean corpuscular volume; ALT, alanine aminotransferase; TSH, thyroid stimulating hormone
aData available
bIncludes only measurements made by a pediatrician at the time of gastrointestinal endoscopy
cUpper limit of the assay 120.0 U/l