Table 3.
Association between histologic and symptomatic presentation and growth disturbance
| n a | Growth failure, % | Odds ratio | 95 % CI | P value | |
|---|---|---|---|---|---|
| Degree of small-bowel mucosal villous atrophy | |||||
| Partial | 174 | 20.7 | 1 | ||
| Subtotal | 194 | 34.5 | 2.02 | 1.26 - 3.24 | 0.003 |
| Total | 126 | 52.4 | 4.22 | 2.54 - 7.00 | <0.001 |
| Severity of symptomsb | |||||
| Mild | 258 | 28.7 | 1 | ||
| Moderate | 107 | 35.5 | 1.37 | 0.85 - 2.21 | 0.198 |
| Severe | 43 | 58.1 | 3.45 | 1.78 - 6.70 | <0.001 |
| Asymptomatic | 121 | 37.2 | 1.47 | 0.93 - 2.33 | 0.097 |
| Diarrhea | |||||
| No | 319 | 32.3 | 1 | ||
| Yes | 181 | 37.6 | 1.26 | 0.86 - 1.85 | 0.232 |
| Abdominal pain | |||||
| No | 267 | 42.7 | 1 | ||
| Yes | 230 | 25.7 | 0.46 | 0.32 - 0.68 | <0.001 |
| Constipation | |||||
| No | 425 | 35.8 | 1 | ||
| Yes | 72 | 26.4 | 0.64 | 0.37 - 1.13 | 0.124 |
| Vomiting | |||||
| No | 466 | 32.4 | 1 | ||
| Yes | 32 | 59.4 | 3.05 | 1.47 - 6.34 | 0.003 |
| Anemia | |||||
| No | 420 | 32.4 | 1 | ||
| Yes | 91 | 37.4 | 1.25 | 0.78 - 2.00 | 0.361 |
aData available
bGrowth failure was not considered as a symptom here at diagnosis in 530 children with celiac disease