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. 2015 Oct 5;15:649. doi: 10.1186/s12885-015-1649-3

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© Beumer et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Synergy in cell killing was seen between carboplatin and Chk1 kinase inhibitor (UCN-01) in 239 T, at the higher response range, and 201 T. However, synergy was only seen in 54 T between carboplatin and ATR kinase inhibitor (ETP-46464) at the lower dose range. Exponentially dividing lung cancer cell lines were treated with increasing doses of carboplatin, ATR kinase inhibitor ETP-46464 and Chk1 kinase inhibitor UCN-01 for 48 h and MTT reagent was then added. Calcusyn was used to calculate a combination index (CI), a quantitative measure of the synergy (CI < 1), additivity (CI =1), and antagonism (CI > 1) between drugs. Log-transformed combination indices (CI) are plotted against growth inhibition/effective dose (ED) with corresponding 95 % confidence interval for a representative experiment. Representative examples from at least 3 experiments are shown (mean of 3 replicates)