Table 2. Univariate and multivariate analyses of risk factors associated with all-cause mortality and sudden cardiac death using a Cox proportional hazards model in 312 hemodialysis patients.
All-cause mortality | Sudden cardiac death | |||
---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | |
HR (95% CI) | aHR (95% CI) | HR (95% CI) | aHR (95% CI) | |
Age | 1.07 (1.05–1.09)* | 1.05 (1.02–1.08)* | 1.08 (1.05–1.12)* | 1.07 (1.03–1.12)* |
Female gender | 0.83 (0.52–1.32) | 1.38 (0.75–2.54) | 0.93 (0.46–1.89) | 0.93 (0.35–2.48) |
Dialysis vintage | 1 (0.99–1) | 1 (1–1.006) | 1 (0.99–1.01) | 1.01 (1–1.02) |
Body mass index | 1 (0.93–1.08) | 0.95 (0.87–1.03) | 1.05 (0.95–1.17) | 1.04 (0.9–1.2) |
1.0 mEq/L K dialysate | 0.17 (0.08–0.36)* | 0.16 (0.07–0.37)* | 0.41 (0.17–0.95)* | 0.33 (0.13–0.85)* |
2.5 mEq/L Ca dialysate | 0.6 (0.19–1.9) | 0.70 (0.21–2.3) | 1.37 (0.42–4.55) | 1.82 (0.5–6.6) |
CAD | 2.92 (1.51–5.67)* | 1.89 (0.88–4.07) | 2.9 (0.98–8.56) | 1.7 (0.47–6.08) |
DM | 3.33 (2.09–5.31)* | 2.09 (1.14–3.83)* | 5.12 (2.47–10.6)* | 4.68 (1.72–12.71)* |
Kt/V | 0.26 (0.08–0.85)* | 0.05 (0.01–0.26)* | 0.44 (0.08–2.56) | 0.21 (0.01–4.4) |
Serum albumin | 0.07 (0.03–0.13)* | 0.16 (0.06–0.4)* | 0.08 (0.03–0.23)* | 0.19 (0.04–1.01) |
Hemoglobin | 0.77 (0.62–0.97)* | 0.79 (0.61–1.02) | 0.99 (0.7–1.38) | 0.97 (0.64–1.47) |
Serum K concentration | ||||
Serum K < 4 mEq/L | 3.82 (1.5–9.7)* | 1.92 (0.67–5.5) | 5.37 (1.22–23.65)* | 2.82 (0.52–15.4) |
Serum K 4–5 mEq/L | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
Serum K >5 mEq/L | 0.67 (0.37–1.21) | 2.1 (1.08–4.09)* | 1.32 (0.62–2.85) | 4.11 (1.62–10.41) * |
Serum creatinine | 0.69 (0.61–0.79)* | 0.98 (0.78–1.22) | 0.66 (0.54–0.81)* | 0.93 (0.65–1.34) |
Serum phosphate | 0.64 (0.5–0.83)* | 0.91 (0.64–1.29) | 0.78 (0.53–1.16) | 1.14 (0.67–1.94) |
ALP | 1 (1–1.002) | 1 (1–1.006) | 1 (1–1.004) | 1 (1–1.008) |
Abbreviations: HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval; K, potassium; Ca, calcium; CAD: Coronary artery disease; DM: Diabetes mellitus; ALP: Alkaline phosphatase.
*p value < 0.05.