Table 3. Efficacy of Biochemical Parameters Used for Diagnosing Adrenal Cushing Syndrome.

Parameter	Cut-off value	AUC	95% CI	Sensitivity, %	Specificity, %	PPV, %	NPV, %
ACTH, pmol/L	5.3	0.954	0.889-0.987	84	94	96	79
DHEA-S, nmol/L	2,464	0.810	0.693-0.936	86	85	92	73
Suppression of serum cortisol, %	-33.3	0.950	0.877-0.986	96	91	94	94
Suppression of UFC, %	-61.6	0.997	0.949-1.000	98	94	96	97

AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; ACTH, adrenocorticotropic hormone; DHEA-S, dehydroepiandrosterone sulfate; UFC, urine free cortisol.