Table 1. Baseline Characteristics of the Study Subjects.
Characteristic | NGT | Prediabetes | Male | Female | ||
---|---|---|---|---|---|---|
NGT | Prediabetes | NGT | Prediabetes | |||
No. of subjects | 100 | 120 | 33 | 55 | 67 | 65 |
Age, yr | 67.13±1.69 | 67.20±1.81 | 67.09±1.82 | 67.38±1.94 | 67.15±1.64 | 67.05±1.69 |
BMI, kg/m2 | 23.92±3.25 | 24.30±3.14 | 24.14±2.37 | 23.90±3.41 | 23.82±3.62 | 24.64±2.88 |
WC, cm | 80.77±8.14 | 82.42±8.54 | 82.21±6.94 | 80.87±8.48 | 80.05±8.62 | 83.72±8.43a |
HC, cm | 91.45±6.23 | 92.78±6.53 | 91.11±6.45 | 91.16±6.69 | 91.61±6.16 | 94.14±6.11a |
Waist-to-hip ratio | 0.88±0.07 | 0.88±0.05 | 0.90±0.10 | 0.88±0.05 | 0.87±0.05 | 0.88±0.05 |
Total body fat, kg | 16.68±5.52 | 17.7±5.86 | 17.34±3.75 | 17.54±6.92 | 16.36±6.21 | 17.89±4.83 |
Visceral fat, kg | 2.11±0.88 | 2.36±0.91a | 2.14±0.61 | 2.27±0.97 | 2.09±0.99 | 2.44±0.86a |
Total body fat ratio | 27.59±6.31 | 28.53±6.99 | 29.31±5.10 | 28.71±7.82 | 26.74±6.70 | 28.38±6.27a |
Visceral fat ratio | 10.33±2.95 | 11.49±2.67b | 10.54±2.64 | 11.50±2.91 | 10.23±3.10 | 11.48±2.48a |
Total muscle, kg | 39.42±6.98 | 39.90±7.03 | 37.33±6.21 | 37.95±5.91 | 40.45±7.15 | 41.58±7.52 |
Fasting glucose, mmol/L | 4.91±6.35 | 5.38±0.55b | 4.94±0.36 | 5.36±0.55b | 4.90±0.35 | 5.39±0.55b |
2-Hour glucose, mmol/L | 6.13±1.06 | 8.10±1.74b | 6.34±0.84 | 8.21±1.59b | 6.03±1.15 | 8.01±1.86b |
Fasting insulin, pmol/L | 52.16±17.15 | 64.31±36.18b | 53.48±11.95 | 65.84±40.98a | 51.46±19.24 | 62.99±31.81a |
2-Hour insulin, pmol/L | 281.76±158.00 | 362.74±300.30b | 274.05±132.02 | 358.29±207.79a | 285.51±170.15 | 366.56±362.95 |
HbA1c, % | 5.25±0.27 | 5.63±0.36b | 5.29±0.19 | 5.66±0.31b | 5.23±0.22 | 5.60±0.40b |
HOMA-IR index | 1.65±0.58 | 2.24±1.40b | 1.69±0.42 | 2.29±1.57a | 1.62±0.65 | 2.21±1.25b |
QUICKI | 0.35±0.02 | 0.34±0.02b | 0.35±0.01 | 0.34±0.02b | 0.36±0.02 | 0.34±0.02b |
TC, mmol/L | 5.30±0.96 | 5.72±1.00b | 5.59±0.88 | 5.73±1.09 | 5.15±0.98 | 5.72±0.92b |
TG, mmol/L | 1.69±0.97 | 2.04±1.19a | 1.77±0.88 | 2.14±1.22 | 1.66±1.02 | 1.96±1.17 |
HDL-C, mmol/L | 1.18±0.27 | 1.18±0.30 | 1.17±0.28 | 1.20±0.33 | 1.19±0.26 | 1.18±0.23 |
LDL-C, mmol/L | 3.14±0.83 | 3.41±0.83b | 3.44±0.76 | 3.39±0.89 | 2.99±0.82 | 3.43±0.78b |
Adiponectin, µg/mL | 12.71±4.76 | 10.39±4.56b | 14.07±4.68 | 10.72±4.74a | 11.91±4.67 | 9.86±4.14a |
PWV, m/s | 15.30±2.70 | 16.13±3.40a | 18.29±2.33 | 18.86±2.60 | 13.83±1.28 | 14.04±1.03 |
SBP, mm Hg | 131.17±15.99 | 136.87±16.60b | 139.58±15.25 | 145.76±16.43 | 127.03±14.77 | 129.34±12.67 |
DBP, mm Hg | 82.66±9.51 | 85.78±10.14b | 86.97±9.28 | 88.89±10.84 | 80.54±8.95 | 83.15±8.77 |
AST, U/L | 27.04±7.82 | 29.30±10.32 | 26.51±6.62 | 30.85±11.56 | 27.29±8.38 | 27.98±13.47 |
ALT, U/L | 22.29±12.07 | 26.49±12.28a | 21.78±10.50 | 26.14±10.81 | 22.53±12.83 | 26.78±13.47 |
γ-GTP, U/L | 24.54±23.29 | 34.21±42.06a | 21.42±13.36 | 32.23±31.80a | 26.07±26.83 | 35.89±49.29 |
hs-CRP, mg/dL | 1.47±2.11 | 1.98±3.84 | 1.49±2.13 | 1.47±2.11 | 1.45±2.03 | 2.41±4.83a |
Ferritin, µg/L | 67.64±50.06 | 102.31±97.67b | 68.87±43.86 | 102.06±93.80 | 67.03±53.15 | 102.53±101.56a |
Values are expressed as mean±SD. Two-hour glucose and 2-hour insulin represent glucose and insulin levels at 120 minutes after a glucose challenge. NGT, normal glucose tolerance; BMI, body mass index; WC, waist circumference; HC, hip circumference; HbA1c, glycated hemoglobin; HOMA-IR, homeostasis model assessment of insulin resistance; QUICKI, quantitative insulin sensitivity check index; TC, total cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; PWV, pulse-wave velocity; SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyl transpeptidase; hs-CRP, high-sensitivity C-reactive protein.
aP<0.05 vs. NGT; bP<0.01 vs. NGT.