Fig. 4.

c-RSV-treated HSP-VEGFA-MSC upregulates expression of anti-oxidant-related genes and VEGFA in PPE-induced emphysema mice. Real-time RT-PCR was performed to analyze the expression of the anti-oxidant-related genes Nrf 2 (a), HO-1 (b), MnSOD (c), and growth factor VEGFA (d) in the lung tissues of the animals that received PBS, the PPE group, and PPE group that received either c-RSV or HSP-VEGFA-MSC with or without c-RSV treatment for 8 weeks following PPE administration on day 14. Values are normalized to the Gapdh values and expressed relative to the PBS group. *P < 0.05, and **P < 0.01. Each dot represents an individual mouse with the mean shown for n ≥ 9 per group