Table 1. Clinical and laboratory features of each AT individual.
Family | Gender | Age (year) | Age at onset (year) | Presenting feature | SARA(score) | ICARS(score) | Bain MRI | α-fetoprotein(ng/ml) a | Immunoglobulins | ||
---|---|---|---|---|---|---|---|---|---|---|---|
lgG(g/L) b | lgA(g/L) c | lgM(g/L) d | |||||||||
FAT–1 | male | 7 | 2 | ataxia, oculocutaneous telangiectasia | 14 | 18 | cerebellar atrophy | 350 | 3.68 | 0.51 | 1.53 |
FAT–2 | female | 10 | 4 | ataxia, oculocutaneous telangiectasia, dysarthria | 25 | 44 | cerebellar atrophy | 376 | 2.32 | 1.03 | 1.23 |
FAT–3 | male | 7 | 2 | ataxia, oculocutaneous telangiectasia | 16 | 22 | cerebellar atrophy | 183 | 5.36 | 1.16 | 1.77 |
Note: SARA: Scale for Assessment and Rating of Ataxia.
ICARS: International Co-operative Ataxia Rating Scale.
MRI: Magnetic Resonance Imaging.
a. Range of blood α-fetoprotein normal value: 0–13.6 ng/ml;
b. Range of blood IgG normal value: 7.23–16.85 g/L;
c. Range of blood IgA normal value: 0.69–3.82 g/l;
d. Range of blood IgM normal value: 0.63–2.77 g/l.