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. 2015 Oct 6;11(10):e1005542. doi: 10.1371/journal.pgen.1005542

Fig 2. EPRAP in bone marrow–derived cells attenuates colitis and colitis-induced tumorigenesis.

Fig 2

Four kinds of chimeric mice were generated by adoptive bone marrow transplantation: (A) Representative photographs of colons with adoptive bone marrow transplantation. (B) Percent changes in colon length expressed relative to DSS-free water controls in each group. (n = 4–8 each). (C) Histological colitis scores (n = 4–8 each). (D) Representative H&E staining of rectal sections. Scale bars: 100 μm. (E) Representative photographs of colons at the end of AOM/DSS treatment. (F) The number of colonic tumors per mouse, with the size distribution (left) and the total number (right) in each group (n = 4–9 each). (G) EPRAP did not directly affect cell proliferation. DLD-1 cell proliferation was determined by MTS assay (over expression of EPRAP, left; knockdown of EPRAP, right). Data represent fold induction of absorbance compared with mock or negative control. All values represent means ± SEM. *P < 0.05, **P < 0.01.