. 2015 Jul 21;20(1-2):63–73. doi: 10.1007/s10911-015-9336-1

Table 1.

Expression of ER and PR in distinct normal human mammary epithelial subpopulations

Markers	Phenotype	Description	ER expression	PR expression	Detection method
CD10 CD24 CD44 [33]	CD10⁻ CD24⁻ CD44⁺	Stem/Progenitor cells	–	+/−	Semi-quantitative RT-PCR^a
EpCAM CD49f CD133 MUC1 CD10 THY1 [28]	EpCAM⁺ CD49f ⁻	Mature Luminal Cells	++	++	Long SAGE^b and Affimetrix analysis, qRT-PCR^c
	MUC1⁺CD133⁺
	CD10⁻ THY1⁻
	EpCAM⁺ CD49f⁺	Bipotent progenitors	+	++
	MUC1⁻ CD133⁻
	CD10⁺ THY1⁺
	EpCAM⁺ CD49f⁺	Luminal-restricted progenitors	+++	+
	MUC1⁺ CD133⁺
	CD10⁻ THY1⁻
CD31/CD45 (Lin^d) EpCAM CD49f ALDH ErbB3 [29]	Lin⁻ EpCAM⁺CD49f⁻	Mature Luminal cells	+++	+++	qRT-PCR
	Lin⁻ EpCAM⁺ CD49f⁺ ALDH⁺ ErbB3⁺	Luminal progenitors (High CFC frequency)	++	++
	Lin⁻ EpCAM⁺ CD49f⁺ ALDH ^- ErbB3⁺	Luminal progenitors (Low CFC frequency)	++	++
CD31/CD45/CD235a (Lin) EpCAM CD49f [25, 26]	Lin⁻ EpCAM⁺ CD49f⁻	Mature Luminal cells	+++	+++	qRT-PCR; ICC^e (% of positive cells)
	Lin⁻ EpCAM⁺ CD49f⁻	Mature Luminal cells	55 %	71 %
	Lin⁻ EpCAM⁺ CD49f⁺	Luminal Progenitor Cells	+	+
	Lin⁻ EpCAM⁺ CD49f⁺	Luminal Progenitor Cells	28 %	2 %
	Lin⁻ EpCAM⁻ CD49f^High	MaSC-enriched Basal cells	+/−	+
	Lin⁻ EpCAM⁻ CD49f^High	MaSC-enriched Basal cells	0.2 %	0.0 %
ALDH [27]	ALDH⁺	Stem/progenitor cells	0 %	ND^f	ICC; Flow cytometry (% of positive cells)

^a RT-PCR reverse transcription polymerase chain reaction

^b LongSAGE long serial analysis of gene expression

^c qRT-PCR quantitative Real-Time PCR

^d Lin lineage

^e ICC immunocytochemistry

^f ND not determined