Table 1.
Baseline characteristics
| Surgical main cohorts | Surgical sub cohorts | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number 13,015 | Reoperateda | Number 13,015 | |||||||
| PrimaryBCT | PrimaryMTX | BCT | MTX | BCTonce | BCTreop. | BCT-MTX | MTX once | MTX reop. | |
| Number of patients | 8065 | 4950 | 1481 | 164 | 6583 | 1287 | 194 | 4786 | 164 |
| Proportion of patients | 62 | 38 | 50.6 | 9.9 | 1.5 | 36.7 | 1.3 | ||
| Median follow-up time | 7.3 years | 7.0 years | 7.3 years | 7.5 years | 8.7 years | 7.0 years | 7.0 years | ||
| Proportion RT | 99.3 | 30.7 | 100 | 100 | 70.1 | 30.3 | 43.3 | ||
| Year of diagnosis | Annual proportion (100 %) | Reoperateda | Annual proportion (100 %) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BCT | MTX | ||||||||
| 1998 | 34 % (264) | 66 % (512) | 16 % | 3.3 % | 29 % | 3.1 % | 2.2 % | 63.8 % | 2.2 % |
| 1999 | 35 % (279) | 65 % (520) | 18 % | 6.3 % | 29 % | 3.9 % | 2.4 % | 61.0 % | 4.1 % |
| 2000 | 41 % (364) | 59 % (519) | 14 % | 3.5 % | 35 % | 4.0 % | 1.8 % | 56.7 % | 2.0 % |
| 2001 | 53 % (482) | 47 % (422) | 21 % | 4.3 % | 42 % | 9.2 % | 1.9 % | 44.7 % | 2.0 % |
| 2002 | 63 % (736) | 37 % (436) | 23 % | 3.9 % | 49 % | 11.9 % | 2.2 % | 35.8 % | 1.5 % |
| 2003 | 72 % (967) | 28 % (384) | 23 % | 3.6 % | 55 % | 14.9 % | 1.6 % | 27.4 % | 1.0 % |
| 2004 | 73 % (1005) | 26 % (368) | 20 % | 2.2 % | 58 % | 13.9 % | 1.0 % | 26.2 % | 0.6 % |
| 2005 | 72 % (1042) | 28 % (407) | 17 % | 2.7 % | 60 % | 10.8 % | 1.2 % | 27.3 % | 0.8 % |
| 2006 | 71 % (962) | 29 % (388) | 18 % | 2.8 % | 59 % | 11.0 % | 1.6 % | 27.9 % | 0.8 % |
| 2007 | 68 % (990) | 32 % (465) | 17 % | 1.3 % | 57 % | 10.5 % | 0.9 % | 31.5 % | 0.4 % |
| 2008 | 65 % (974) | 35 % (529) | 14 % | 2.1 % | 56 % | 8.3 % | 0.9 % | 34.5 % | 0.7 % |
| Age at diagnosis (years) | |||||||||
| <30 | 61 % (31) | 39 % (20) | 26 % | 5.0 % | 45 % | 16 % | 0 % | 37 % | 2.0 % |
| 30–39 | 56 % (287) | 44 % (222) | 26 % | 5.0 % | 42 % | 11 % | 3.9 % | 41 % | 2.2 % |
| 40–49 | 66 % (1467) | 34 % (761) | 20 % | 4.5 % | 53 % | 11 % | 2.1 % | 33 % | 1.5 % |
| 50–59 | 72 % (3024) | 29 % (1203) | 19 % | 3.7 % | 58 % | 12 % | 1.5 % | 27 % | 1.0 % |
| 60–69 | 72 % (2515) | 29 % (1024) | 17 % | 2.5 % | 59 % | 11 % | 1.1 % | 28 % | 0.7 % |
| 70–79 | 38 % (651) | 62 % (1062) | 16 % | 2.9 % | 32 % | 5 % | 1.3 % | 60 % | 1.8 % |
| ≥80 | 12 % (90) | 88 % (658) | 13 % | 2.6 % | 10 % | 1 % | 0.5 % | 86 % | 2.3 % |
| TNM stage | |||||||||
| T1N0 | 75 % (5165) | 25 % (1686) | 17 % | 2.4 % | 63 % | 11 % | 1.7 % | 24 % | 0.6 % |
| T2N0 | 44 % (888) | 56 % (1140) | 20 % | 2.4 % | 35 % | 8 % | 1.2 % | 55 % | 1.3 % |
| T1N1 | 60 % (1340) | 40 % (893) | 22 % | 4.4 % | 47 % | 11 % | 2.0 % | 38 % | 1.7 % |
| T2N1 | 35 % (672) | 65 % (1231) | 20 % | 4.6 % | 28 % | 7 % | 0.5 % | 62 % | 3.0 % |
| Histology | |||||||||
| Ductal c. | 62 % (6618) | 38 % (3981) | 18 % | 3.5 % | 51 % | 10 % | 1.5 % | 36 % | 1.3 % |
| Lobular c. | 58 % (756) | 42 % (549) | 24 % | 2.6 % | 44 % | 12 % | 2.0 % | 41 % | 1.1 % |
| Other c. | 62 % (691) | 38 % (420) | 19 % | 2.6 % | 51 % | 10 % | 1.3 % | 37 % | 1.0 % |
| Grade | |||||||||
| I | 73 % (2261) | 27 % (844) | 16 % | 2.7 % | 61 % | 11 % | 1.1 % | 26 % | 0.7 % |
| II | 61 % (3600) | 39 % (2259) | 17 % | 3.3 % | 51 % | 9 % | 1.3 % | 37 % | 1.3 % |
| III | 54 % (1650) | 46 % (1382) | 23 % | 4.1 % | 42 % | 10 % | 2.3 % | 44 % | 1.8 % |
| Unknown | 54 % (554) | 46 % (465) | 22 % | 2.4 % | 42 % | 10 % | 1.7 % | 45 % | 1.1 % |
BCT once BCT operated once, BCT reop. BCT followed by reoperation, BCT-MTX BCT followed by MTX, MTX once MTX operated once, MTX reop. MTX with reoperation
aBCT reoperated is calculated by number of primary BCT undergoing BCT reoperation and BCT followed by MTX. MTX reoperated is calculated by number of primary MTX undergoing MTX with reoperation