Table 3.

Crude and adjusted HR on overall and breast cancer death in women with early-stage breast cancer

	Crude				Adjusted
	Overall death		Breast cancer death		Overall death		Breast cancer death
	HR	95 % CI	HR	95 % CI	HR	95 % CI	HR	95 % CI
Surgical main cohorts
Primary BCT	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
Primary MTX	3.11	(2.86–3.38)	3.16	2.79–3.57	1.65	1.50–1.82	1.64	1.43–1.88
Surgical subcohorts
BCT once	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
BCT reop.	1.05	0.87–1.26	1.38	1.07–1.77	1.04	0.86–1.25	1.28	0.99–1.64
BCT-MTX	1.90	1.39–2.58	2.92	1.97–4.33	1.69	1.24–2.31	2.19	1.47–3.26
MTX once	3.90	2.89–3.47	3.35	2.92–3.85	1.68	1.51–1.86	1.72	1.48–2.01
MTX reop.	4.56	3.60–5.78	7.93	5.94–10.58	2.50	1.96–3.19	3.40	2.53–4.58
Year of diagnosis
1998	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
1999	0.93		0.79		0.89		0.73
2000	0.87		0.78		0.9		0.77
2001	0.87		0.75		1.05		0.83
2002	0.69		0.53		0.89		0.63
2003	0.77		0.58		0.99		0.76
2004	0.64		0.45		0.89		0.62
2005	0.69		0.34		0.87		0.44
2006	0.6		0.29		0.75		0.39
2007	0.59		0.22		0.77		0.30
2008	0.53		0.17		0.66		0.23
Age categories (years)
<30	2.15		3.12		1.51		1.78
30–39	1.59		2.42		1.15		1.46
40–49	0.98		1.21		0.82		0.91
50–59	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
60–69	1.42		0.96		1.52		1.11
70–79	3.71		2.15		2.98		1.66
≥80	8.38		2.92		6.04		2.13
TNM stage
T1N0M0	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
T2N0M0	2.38		2.95		1.41		1.83
T1N1M0	1.56		2.86		1.92		2.18
T2N1M0	3.34		6.57		3.37		3.95
Histology
Ductal c.	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
Lobular c.	1.04		0.88		0.93		0.91
Other	1.03		0.89		1.04		1.02
Grade
I	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)	1.00	(Reference)
II	1.69		2.61		1.41		1.98
III	2.47		5.65		1.92		3.53
Unknown	1.73		2.84		1.30		1.99

Numbers in italic are not significant (p > 0.05)