Table 4.
Crude and adjusted HR on overall and breast cancer death in women with early-stage breast cancer stratified in women <50 years, women aged 50–69 years, women aged ≥70 years, and T1N0M0 grade 1
| Crude | Adjusted | ||||
|---|---|---|---|---|---|
| Overall death | Breast cancer death | Overall death | Breast cancer death | ||
| HR | HR | HR | HR | ||
| Women aged < 50 years | |||||
| Surgery | Nr | ||||
| Primary BCT | 1785 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Primary MTX | 1003 | 2.10 (1.71–2.59) | 2.51 (1.98–3.18) | 1.43 (1.15–1.80) | 1.58 (1.22–2.04) |
| Surgical subcohorts | |||||
| BCT once | 1415 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| BCT reop. | 304 | 0.88 (0.57–1.35) | 0.84 (0.50–1.41) | 0.85 (0.54–1.31) | 0.80 (0.48–1.35) |
| BCT-MTX | 66 | 1.51 (0.79–2.87) | 1.50 (0.70–3.23) | 1.45 (0.75–2.79) | 1.32 (0.60–2.87) |
| MTX once | 957 | 1.96 (1.56–2.46) | 2.32 (1.79–3.01) | 1.35 (1.06–1.72) | 1.46 (1.11–1.93) |
| MTX reop. | 46 | 5.42 (3.42–8.61) | 6.41 (3.87–10.62) | 2.95 (1.83–4.75) | 3.12 (1.86–5.25) |
| Women aged 50–69 years | |||||
| Surgery type | |||||
| Primary BCT | 5539 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Primary MTX | 2227 | 2.40 (2.12–2.72) | 3.26 (2.74–3.88) | 1.74 (1.52–2.00) | 1.64 (1.35–1.99) |
| Surgical subcohorts | |||||
| BCT once | 4546 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| BCT reop. | 891 | 1.14 (0.90–1.43) | 1.83 (1.34–2.49) | 1.09 (0.87–1.39) | 1.71 (1.25–2.33) |
| BCT-MTX | 102 | 2.24 (1.47–3.40) | 3.95 (2.32–6.71) | 2.03 (1.33–3.09) | 2.91 (1.70–6.28) |
| MTX once | 2157 | 2.42 (2.13–2.78) | 3.65 (3.99–4.45) | 1.77 (1.35–2.05) | 1.85 (1.49–2.30) |
| MTX reop. | 70 | 5.35 (3.77–7.59) | 11.70 (7.77–17.62) | 3.32 (2.31–4.78) | 4.09 (2.66–6.28) |
| Women aged ≥ 70 years | |||||
| Surgery type | |||||
| Primary BCT | 741 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Primary MTX | 1720 | 2.15 (1.84–2.51) | 2.23 (1.67–2.96) | 1.56 (1.31–1.85) | 1.50 (1.10–2.05) |
| Surgical subcohorts | |||||
| BCT once | 622 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| BCT reop. | 92 | 1.16 (0.77–1.76) | 1.05 (0.47–2.32) | 1.01 (0.72–1.66) | 0.83 (0.34–1.84) |
| BCT MTX | 27 | 1.42 (0.75–2.69) | 2.68 (1.06–6.76) | 1.30 (0.68–2.47) | 1.92 (0.75–4.90) |
| MTX once | 1672 | 2.25 (1.89–2.67) | 2.36 (1.72–3.23) | 1.61 (1.33–1.93) | 1.52 (1.08–2.13) |
| MTX reop. | 48 | 1.67 (1.06–2.64) | 2.82 (1.43–5.62) | 1.36 (0.85–2.16) | 2.14 (1.06–4.31) |
| T1N0M0 grade 1 | |||||
| Surgery type | |||||
| Primary BCT | 1451 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Primary MTX | 366 | 2.61 (1.91–3.56) | 3.52 (1.80–6.90) | 1.77 (1.22–2.56) | 2.07 (0.94–4.56) |
| Surgical sub cohorts | |||||
| BCT once | 1245 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| MTX once | 358 | 2.61 (1.88–3.61) | 4.73 (2.22–10.10) | 1.80 (1.23–2.63) | 2.80 (1.18–6.61) |
In the T1N0M0 grade 1 strata, 17 primary BCT died and 18 primary MTX died
Numbers in italics are not significant (p > 0.05)