Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding and cAMP Activities of Selected Peptides at Human Melanoma Cells (A375)
| Peptide | Sequence | IC50 (nM) | Binding Efficiency | EC50 (nM) | Act% |
|---|---|---|---|---|---|
| 15 | Ac-Nle-c[Asp-(NMe)His-DNal(2′)-(NMe)Arg-Trp-Lys]-NH2 | 14.8 ± 2 | 100 ± 10 | 22 ± 2.5 | NA |
| 28 | Ac-Nle-c[Asp-(NMe)His-DNal(2′)-(NMe)Arg-(NMe)Trp-(NMe)Lys]-NH2 | 8.7 ± 1 | 100 ± 10 | 20 ±2 | NA |
| MT-II | Ac-Nle-c[Asp-His-d-Phe-Arg-Trp-Lys]-NH2 | 6.7 ± 2.9 | 100 ± 10 | 110 ± 0.6 | 100 |
| 1 | Ac-Nle-c[Asp-His-DNal(2′)-Arg-Trp-Lys]-NH2 | 100 ± 96 | 80 ± 34 | 3.3 ± 2.6 | NA |
