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Quantification of ECG-based biomarkers for TdP patients after sotalol challenge (filled diamonds), and healthy volunteers before (open circles), after sotalol administration (gray squares) and after the second sotalol dose (filled triangles). (A and B) Rate adaptation biomarkers of Tpe and QT intervals (t90Tpe and t90QT, respectively). (C) Results corresponding to the biomarker DRest, quantifying dispersion of APD restitution. (D) Results for the QTc interval.
