Table 1.

[20 Percentile–80 percentile] bounds for the different ECG biomarkers in healthy subjects before and after sotalol intake, whole range of healthy subjects after second sotalol dose, and values for the three sotalol-induced TdP patients (TdP1, TdP2 and TdP3).

	RR [ms]	DRest	QTc [ms]	t90Tpe [s]	t90QT [s]	Tpec [ms]
Healthy	776–925	0.025–0.058	384–407	77–227	86–200	82–98
Healthy + Sotalol	815.8–951	0.033–0.054	394–424	93–259	104–210	83–96
Healthy + 2nd dose	840–1100	0.029–0.068	384–427	92–247	122–243	69–102
TdP1 + Sotalol	944.6	0.22	548	292	285	116
TdP2 + Sotalol	1158.1	0.18	436	268	267	77
TdP3 + Sotalol	902.3	0.21	480	251	285	107

Biomarkers analyzed were dispersion of APD restitution (DRest), QTc, the rate adaptation times of QT and T_pe intervals (t₉₀^Tpe and t₉₀^QT) and T_pec.