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. 2015 Oct 7;35(40):13587–13598. doi: 10.1523/JNEUROSCI.2194-15.2015

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Copyright © 2015 the authors 0270-6474/15/3513588-12$15.00/0

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Figure 5. — REM and NREM sleep states are reduced and fragmented in AS model mice during the active phase. A, Time spent in REM sleep across the day in Ube3a^m+/p+ and Ube3a^m−/p+ mice. Two-way ANOVA revealed significant main effects of time and genotype (main effect of time-of-day, F_(11,1) = 51.7, p < 0.001; main effect of genotype, F_(11,1) = 8.2, p = 0.015), as well as a significant interaction of time-of-day and genotype (interaction: F_(11,1) = 4.0, p < 0.001). B, Number of REM bouts across the day in Ube3a^m+/p+ and Ube3a^m−/p+ mice. Two-way ANOVA revealed a significant main effect of time-of-day (F_(11,1) = 24.4, p < 0.001) but not genotype (F_(11,1) = 1.8, p > 0.20), and a significant interaction of time and genotype (interaction: F_(11,1) = 2.5, p = 0.006). C, Duration of REM bouts across the day in Ube3a^m+/p+ and Ube3a^m−/p+ mice. Two-way ANOVA revealed a statistically significant main effect of genotype (F_(11,1) = 9.6, p = 0.009) but not time (F_(11,1) = 2.3, p = 0.15), and no interaction of time-of-day and genotype (F_(11,1) = 1.8, p = 0.057). D, Time spent in NREM sleep during this period. Two-way ANOVA revealed a significant main effect of time-of-day (F_(11,1) = 31.3, p < 0.001) but not genotype (F_(11,1) = 0.24, p = 0.63), and a significant interaction of time-of-day and genotype (F_(11,1) = 4.3, p < 0.001). E, Number of NREM bouts across the day in Ube3a^m+/p+ and Ube3a^m−/p+ mice. Two-way ANOVA revealed a significant main effect of time (F_(11,1) = 9.0, p < 0.001) but not genotype (F_(11,1) = 2.4, p = 0.15), and a significant interaction of time-of-day and genotype (F_(11,1) = 2.9, p = 0.002). F, Duration of NREM bouts across the day in Ube3a^m+/p+ and Ube3a^m−/p+ mice. Two-way ANOVA revealed a significant main effect of time-of-day (F_(11,1) = 4.0, p < 0.001) but not genotype (F_(11,1) = 1.3, p = 0.29), and a significant interaction of time and genotype (F_(11,1) = 1.9, p = 0.044). Data in all panels are shown as percentages of time spent in each arousal state, bout number, or mean bout duration of each 2 h block within each mouse, averaged within genotypes (mean ± SEM; n = 6 Ube3a^m+/p+ or n = 8 Ube3a^m−/p+ mice). Asterisk indicates significant differences between genotypes at the indicated times (p < 0.05, post hoc t test; Bonferroni corrected).