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. 2015 Oct 7;35(40):13713–13719. doi: 10.1523/JNEUROSCI.1403-15.2015

Figure 3.

Figure 3.

Supplementation with l-serine or removal of l-alanine rescues the mutant SPTLC1C133W condition. A, B, DRG from WT and SPTLC1C133W mice treated with 10 mm l-serine (A) or with AFM (B) (n = 3) were stained with p-ERM and NeuH. Scale bar, 20 μm. C, Representative images of WT and SPTLC1C133W DRG growth cones before and after treatment. D, SPTLC1C133W DRG treated with l-serine or AFM exhibit significantly decreased neurite length. WT DRG show no significant difference in neurite length after l-serine or AFM. E, Expression of p-ERM is significantly decreased in SPTLC1C133W DRG growth cones after treatment with l-serine or AFM. There is no significant difference in p-ERM expression in WT DRG after l-serine or AFM. F, Sholl analysis revealed no difference in branching of WT DRG after l-serine or AFM treatment. G, Branching of SPTLC1C133W DRG after l-serine or AFM treatment is reduced to levels similar to WT DRG.