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. 2015 Oct 7;35(40):13713–13719. doi: 10.1523/JNEUROSCI.1403-15.2015

Figure 4.

Figure 4.

Supplementation with l-alanine increases WT DRG branching and p-ERM expression. A, DRG from WT and SPTLC1C133W mice treated with 10 mm l-alanine (n = 3) were stained with p-ERM and NeuH. Scale bar, 20 μm. B, Representative images of WT and SPTLC1C133W DRG growth cones before and after treatment. C, Treatment with l-alanine has no significant effect on neurite length of WT or SPTLC1C133W DRG. D, Expression of p-ERM is significantly increased in WT DRG growth cones after l-alanine treatment. l-alanine treatment had no significant effect on p-ERM expression in SPTLC1C133W DRG. E, Sholl analysis revealed branching of WT DRG after l-alanine treatment is elevated to levels similar to mutant SPTLC1C133W DRG. F, Branching of SPTLC1C133W DRG is not altered after l-alanine treatment.