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. 2015 Sep 18;6:8301. doi: 10.1038/ncomms9301

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(a) Spearman's correlation coefficient (ρ) and hierarchical clustering analyses of transcriptome data from adult tissues of the brachiopod, Lingula, and Pacific oyster, Crassostrea, in which 6,315 orthologous gene pairs were identified. An adult Lingula is shown with the dorsal shell removed and the anus opening to the right. (b) Genes involved in formation of vertebrate bone, mollusc shell and Lingula shell are compared in biomineralization-capable metazoans. Hierarchical clustering was performed in vertebrate bone formation-associated genes. Numbers of genes analysed are indicated in the parentheses. Shark, C. milii; pearl oyster, Pinctada fucata; sea snail, L. gigantea. BMP, bone morphogenetic protein; FGF, fibroblast growth factor; SCPPs, secreted calcium-binding phosphoproteins; SPARCs, secreted proteins acidic and rich in cysteine.