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. 2015 Sep 18;6:8301. doi: 10.1038/ncomms9301

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(a–h) Confocal images of Lingula larvae from one-pair cirri to three-pair cirri stages. (a–d) Filamentous actin (F-actin) staining shows the cellular structure of larvae. Cytoplasmic membranes and nuclei are labelled with CellMask (grey) and DAPI (blue), respectively. Inset in c shows the cell boundary at higher magnification. (e–h) Activation of BMP signalling is monitored by nuclear signals of phosphorylated Smad1/5/9 (pSmad, red). Inset in e shows nuclear pSmad signals at higher magnification. It is noteworthy that signals are localized at the margin of mantle lobes (arrows). Orientation of embryos is indicated at the bottom-right corner of each panel. cr, cirrus (cirri); mf, muscle fiber; ml, mantle lobe; mo, mouth; sh, embryonic shell; tn, tentacle. Scale bars, 50 μm.