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. 2015 Sep 18;6:8301. doi: 10.1038/ncomms9301

Figure 6. Fibrillar collagens in Lingula and vertebrates have different origins.

Figure 6

(a) Phylogenetic analysis of the collagen triple helix region using the maximum likelihood method with the LG model (159 genes, 542 amino acids, 100 bootstrap replicates). Expression of gene models is supported by the shell proteome (square) and transcriptome (circle). Numbers indicate Lingula gene IDs. (b) Domain structure of selected collagens. Expression of proteins is shown in grey boxes. C4, type IV collagen C4 domain; COLFI, fibrillar collagens C-terminal domain; EGF, epidermal growth factor-like domain; EGF_CA, calcium-binding EGF domain; Fxa_inhibition, coagulation Factor Xa inhibitory site; VWC, von Willebrand factor type C domain. (c) Genomic organization of tandem-duplicated collagen genes expressed in mantle and shell. Arrows indicate the direction of transcription. Grey boxes denote exons.