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. 2015 Oct 7;7:190. doi: 10.3389/fnagi.2015.00190

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Copyright © 2015 Randolph and Pavlath.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myofiber structure and cellular progression of myogenesis. Myofibers are surrounded by a basal lamina, underneath which lie satellite cells in close apposition to the myofiber. With injury, satellite cells proliferate and give rise to myoblasts, which differentiate, migrate, adhere, and fuse with one another to form multiple myotubes within the basal lamina scaffold. Myoblasts/myotubes fuse with the stumps of the surviving myofiber and myotubes also fuse with each other to repair the injured myofiber. Regenerated myofibers are identifiable by the presence of centrally located nuclei. Representative hematoxylin and eosin stained muscle cross-sections from chemically injured murine muscles are provided for each stage of muscle regeneration to illustrate the differential tissue morphology.