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. 2015 Aug 15;192(4):455–467. doi: 10.1164/rccm.201412-2233OC

Figure 4.

Figure 4.

FK506-binding protein 10 (FKBP10) is expressed in interstitial fibroblasts, including myofibroblasts, and interstitial CD68+ macrophages in human idiopathic pulmonary fibrosis (IPF). Representative immunofluorescent stainings of paraffin sections from donor (left panels) and IPF tissue (right panels). Representative FKBP10 immunostaining is always shown in red and 4′,6-diamidino-2-phenylindole (DAPI) in blue. (A) Representative immunofluorescent costainings with α-smooth muscle actin (α-SMA), desmin, podoplanin (T1α), and thyroid transcription factor 1 (TTF1) in green show FKBP10 expression in interstitial fibroblasts but not in alveolar epithelial cells. White squares in the IPF stainings are shown enlarged to the right. Scale bar = 100 μm. (B) Representative immunofluorescent costainings with CD68 show FKBP10 expression in interstitial macrophages (indicated by white arrows). Sections shown are representative stainings from three donors and three patients with IPF. Scale bar = 50 μm.