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. 2015 Aug 15;192(4):520–523. doi: 10.1164/rccm.201503-0522LE

Table 1.

Adjusted Odds Ratios of Asthma-related Outcomes across Preterm Birth Categories*

  Preterm Birth (<37 wk); Ref = Term (37–41 wk)
 Degree of Prematurity; Ref = Full Term (39–41 wk)
Early Preterm (22–31 wk)
 Late Preterm (32–36 wk)
 Early Term (37–38 wk)
AOR 95% CI P Value AOR 95% CI P Value AOR 95% CI P Value AOR 95% CI P Value
Outcome at ages 0–5 yr (N = 2,540)                        
 Diagnosis                        
  Ever asthma (≥1) 2.45 (1.98–3.04) <0.001 5.90 (4.19–8.31) <0.001 1.70 (1.30–2.23) <0.001 1.05 (0.80–1.38) 0.718
  Recurrent asthma (≥2) 2.28 (1.81–2.88) <0.001 4.13 (2.88–5.93) <0.001 1.70 (1.27–2.28) <0.001 0.95 (0.70–1.29) 0.763
  Recurrent asthma (≥4) 2.00 (1.52–2.61) <0.001 4.09 (2.72–6.13) <0.001 1.54 (1.09–2.19) 0.015 1.17 (0.83–1.66) 0.364
  Ever wheezing (≥1) 1.85 (1.48–2.31) <0.001 3.15 (2.21–4.49) <0.001 1.67 (1.26–2.20) <0.001 1.27 (0.97–1.66) 0.084
  Recurrent wheezing (≥2) 2.29 (1.71–3.09) <0.001 4.16 (2.66–6.51) <0.001 1.92 (1.31–2.82) <0.001 1.21 (0.82–1.79) 0.339
  Recurrent wheezing (≥4) 2.85 (1.83–4.43) <0.001 6.17 (3.30–11.55) <0.001 2.12 (1.17–3.82) 0.013 1.20 (0.64–2.26) 0.567
  Ever asthma exacerbation 2.48 (1.94–3.17) <0.001 4.49 (3.08–6.55) <0.001 2.05 (1.50–2.79) <0.001 1.14 (0.82–1.57) 0.435
 Medication                        
  Any asthma medication 2.22 (1.83–2.68) <0.001 5.74 (4.14–7.96) <0.001 1.68 (1.33–2.12) <0.001 1.22 (0.97–1.52) 0.088
  Long-term controller 2.42 (1.89–3.09) <0.001 5.82 (4.03–8.39) <0.001 1.54 (1.12–2.12) 0.008 1.00 (0.72–1.39) 0.988
  SABAs/long-term controller 2.26 (1.87–2.74) <0.001 5.60 (4.03–7.76) <0.001 1.73 (1.36–2.19) <0.001 1.21 (0.96–1.52) 0.109
  Any oral steroid use 2.45 (1.95–3.08) <0.001 5.35 (3.76–7.60) <0.001 1.87 (1.39–2.51) <0.001 1.18 (0.87–1.59) 0.292
Outcome at ages 6–9 yr (N = 1,072)†                        
 Diagnosis                        
  Ever asthma (≥1) 2.28 (1.66–3.12) <0.001 4.92 (2.91–8.31) <0.001 2.04 (1.38–3.01) <0.001 1.46 (0.98–2.16) 0.062
  Recurrent asthma (≥2) 2.94 (2.08–4.15) <0.001 5.68 (3.27–9.86) <0.001 2.46 (1.60–3.80) <0.001 1.22 (0.76–1.95) 0.409
  Recurrent asthma (≥4) 2.40 (1.57–3.67) <0.001 3.92 (2.05–7.47) <0.001 1.97 (1.16–3.36) 0.013 1.10 (0.61–1.98) 0.744
  Ever asthma exacerbation 2.05 (1.35–3.12) <0.001 3.91 (2.04–7.50) <0.001 2.09 (1.21–3.60) 0.008 1.83 (1.07–3.15) 0.029
 Medication                        
  Any asthma medication 2.05 (1.51–2.77) <0.001 3.82 (2.28–6.41) <0.001 1.87 (1.29–2.71) <0.001 1.31 (0.90–1.90) 0.163
  Long-term controller 2.64 (1.84–3.77) <0.001 3.57 (2.03–6.28) <0.001 2.26 (1.47–3.49) <0.001 0.99 (0.61–1.61) 0.972
  SABAs/long-term controller 2.17 (1.59–2.96) <0.001 4.00 (2.37–6.73) <0.001 2.02 (1.38–2.96) <0.001 1.35 (0.91–1.99) 0.133
  Any oral steroid use 2.16 (1.39–3.36) <0.001 3.21 (1.68–6.15) <0.001 1.60 (0.93–2.75) 0.092 0.90 (0.50–1.65) 0.743

Definition of abbreviations: AOR = adjusted odds ratio; CI = confidence interval; Ref = reference; SABAs = short-acting β-agonists.

See Table E1 for description of asthma measures.

*

Adjusted for maternal age, race/ethnicity, marital status, education, history of asthma, maternal persistent smoking during the index pregnancy; child sex and age, followed years, and family member smoking.

†

Wheezing measures were excluded because of low prevalence during ages 6–9 years.