Table 5.

Inflammatory Mediators in Nasal Lavage Fluid

	Control (Mean ± SEM)	CRSsNP (Mean ± SEM)	CRSwNP (Mean ± SEM)
ECP*	61,000 ± 28,000	280,000 ± 106,000	598,000 ± 194,000†
IL-5‡	0.7 ± 0.3	1.0 ± 0.3	26.2 ± 11.2†
IL-13‡	2.6 ± 1.1	1.4 ± 0.3	12.6 ±  5.4†§
Eotaxin-2‡	198 ± 34.6	195 ± 33.2	839 ± 268†§
Eotaxin-3‡	12.2 ± 6.7	81.9 ± 34.8	559 ± 142†§
MCP-4*	4.0 ± 0.4	3.7 ± 0.6	8.0 ± 1.3†§
IL-4‖	4.7 ± 1.3	3.0 ± 1.5	7.7 ± 2.4§
TARC‖	10.6 ± 2.3	7.0 ± 1.4	36.8 ± 20.6§
RANTES	787 ± 211	734 ± 308	863 ± 367
Eotaxin-1	27.2 ± 4.2	25.6 ± 4.8	31.8 ± 5.3
MCP-1	480 ± 162	422 ± 150	685 ± 192
GM-CSF	0.9 ± 0.3	0.7 ± 0.2	0.9 ± 0.3
SCF	3.9 ± 1.5	1.2 ± 0.4	2.7 ± 0.9
IL-6	26.1 ± 8.7	12.0 ± 3.0	230 ± 144
IL-10	3.3 ± 0.8	2.1 ± 0.4	13.7 ± 7.9
IL-33	186 ± 72.2	62.3 ± 15.9	74.0 ± 20.2
IFN-α2	2.0 ± 0.7	2.5 ± 0.5	2.4 ± 0.5
IFN-γ	0.5 ± 0.2	0.3 ± 0.1	0.7 ± 0.3
BCA-1	102 ± 62.8	73.7 ± 22.7	305 ± 65.5
SDF-1α and SDF-1β	0.0 ± 0.0	0.0 ± 0.0	18.0 ± 10.9

Definition of abbreviations: BCA = B cell–attracting chemokine; CRSsNP = chronic rhinosinusitis without nasal polyps; CRSwNP = chronic sinusitis with nasal polyps; ECP = eosinophil cationic protein; MCP = monocyte chemoattractant protein; GM-CSF = granulocyte–macrophage colony–stimulating factor; RANTES = regulated upon activation, normal T-cell expressed and secreted protein; SCF = stem cell factor; SDF = stromal cell–derived factor; TARC = thymus and activation–regulated chemokine.

All values are given as picograms per milliliter. Bold indicates mediators of particular interest.

^*P < 0.01, Kruskal–Wallis test for statistical significance.

^†Significantly different (P < 0.05) compared with control accordng to post hoc analysis using Dunn’s multiple-comparisons test.

^‡P < 0.001, Kruskal–Wallis test for statistical significance.

^§Significantly different (P < 0.05) compared with CRSsNP accordng to post hoc analysis using Dunn’s multiple-comparisons test.

^‖P < 0.05, Kruskal–Wallis test for statistical significance.