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. 2015 Sep 1;192(5):605–617. doi: 10.1164/rccm.201412-2141OC

Figure 6.

Figure 6.

Adjusted prediction formula differentiates cumulative risk of tuberculosis (TB) reactivation in combination subsets of QuantiFERON TB Gold In-Tube (QFT) and flow cytometry (FC) immune-reactive profiles. (A) Cumulative patients’ risk for TB reactivation for combinations of QFT and FC assay CD4+ (region of difference 1 [RD1] peptide antigen [Ag] − negative control [nil]) results (using the optimized FC test cut-offs that differentiate untreated from treated subjects with latent tuberculosis infection). (B) Cumulative patients’ risk for TB reactivation for combinations of QFT and FC assay CD8+ (purified protein derivative [PPD] − nil) results (using the optimized FC test cut-offs). P value estimation by Tukey’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. ns = not significant (P > 0.05). Bar indicates mean value; error bar indicates 95% confidence interval. FC assay CD4+ (RD1 Ag − nil) = FC assay for the percentage of CD25+CD134+ of CD3+CD4+ T cells (RD1 Ag − nil); FC assay CD8+ (PPD − nil) = FC assay for the percentage of CD25+CD134+ of CD3+CD8+ T cells (PPD − nil).