Table 2.
Immunodiagnostic Assays Results and Multiple Comparisons
| Unexposed Subjects (n = 27) | Untreated Subjects with LTBI (n = 21) | Treated Subjects with LTBI (n = 17) | P Value* | P Value† | |
|---|---|---|---|---|---|
| QuantiFERON TB Gold In-Tube, IU/ml | |||||
| Mean ± SD | 0.01 ± 0.02 | 4.17 ± 5.48 | 3.31 ± 4.59 | ||
| Median (IQR) | 0 (0.0–0.01) | 0.69 (0.03–10.25) | 0.89 (0.02–5.98) | ||
| %CD3+CD4+/CD25+CD134+ (RD1 peptides − nil) | <0.0001 | 0.022 | |||
| Mean ± SD | 0.01 ± 0.02 | 0.57 ± 0.89 | 0.06 ± 0.13 | ||
| Median (IQR) | 0 (0.0–0.0) | 0.05 (0.0–0.84) | 0 (0.0–0.04) | ||
| %CD3+CD4+/CD25+CD134+ (PPD − nil) | 0.005 | 0.213 | |||
| Mean ± SD | 0.56 ± 1.95 | 1.24 ± 1.54 | 0.23 ± 0.31 | ||
| Median (IQR) | 0 (0.0–0.16) | 0.39 (0.03–2.40) | 0.20 (0.0–0.27) | ||
| %CD3+CD4+/CD25+CD134+ (Candida Ag − nil) | 1.00 | 0.600 | |||
| Mean ± SD | 0.52 ± 0.60 | 1.01 ± 1.58 | 0.33 ± 0.42 | ||
| Median (IQR) | 0.25 (0.0–1.03) | 0.31 (0.05–1.65) | 0.12 (0.0–0.53) | ||
| %CD3+CD4+/CD25+CD134+ (SEAB/anti-CD3 − nil) | 1.00 | 0.385 | |||
| Mean ± SD | 4.26 ± 3.67 | 3.66 ± 4.08 | 6.25 ± 5.45 | ||
| Median (IQR) | 4.26 (1.15–5.29) | 2.23 (0.01–6.74) | 5.15 (1.89–9.80) | ||
| %CD3+CD8+/CD25+CD134+ (RD1 peptides − nil) | 0.002 | 0.614 | |||
| Mean ± SD | 0.15 ± 0.37 | 0.49 ± 0.66 | 0.27 ± 0.36 | ||
| Median (IQR) | 0.02 (0.0–0.12) | 0.26 (0.05–0.71) | 0.14 (0.02–0.37) | ||
| %CD3+CD8+/CD25+CD134+ (PPD − nil) | 0.001 | <0.001 | |||
| Mean ± SD | 0.06 ± 0.14 | 0.28 ± 0.25 | 0.06 ± 0.12 | ||
| Median (IQR) | 0.0 (0.0–0.07) | 0.21 (0.06–0.56) | 0.0 (0.0–0.04) | ||
| %CD3+CD8+/CD25+CD134+ (Candida Ag − nil) | 0.908 | 0.099 | |||
| Mean ± SD | 0.09 ± 0.15 | 0.18 ± 0.26 | 0.04 ± 0.07 | ||
| Median (IQR) | 0.02 (0.0–0.16) | 0.07 (0.0–0.25) | 0.0 (0.0–0.07) | ||
| %CD3+CD8+/CD25+CD134+ (SEAB/anti-CD3 − nil) | 0.455 | 0.394 | |||
| Mean ± SD | 0.78 ± 0.92 | 0.45 ± 0.61 | 1.01 ± 1.17 | ||
| Median (IQR) | 0.66 (0.26–0.83) | 0.13 (0.0–0.78) | 0.59 (0.03–1.54) |
Definition of abbreviations: Ag = antigen; anti-CD3 = anti-CD3 monoclonal antibodies; IQR = interquartile range; LTBI = latent tuberculosis infection; nil = negative control; PPD = purified protein derivative; RD1 = region of difference 1; SEAB = staphylococcal enterotoxin A and B.
*
P values for comparison between unexposed subjects and untreated LTBI cases by the Dunn’s method for multiple comparison.
†
P value for comparison between treated and untreated LTBI cases by the Dunn’s method for multiple comparison.