Table 6.
Treatment Failure Odds by Specific Therapy
| Therapy | Age ≥30 |
Age <30 |
Age ≥ 30 vs. Age < 30 |
|||
|---|---|---|---|---|---|---|
| Failures/Total | Failure (%) | Failures/Total | Failure (%) | OR (95% CI) | P Value | |
| All treatments | 100/579 | 17.3 | 64/621 | 10.3 | 1.82 (1.30–2.54) | <0.001* |
| All LABA | 69/203 | 34.0 | 35/145 | 24.1 | 1.62 (1.0–2.61) | 0.049* |
| LABA + ICS | 22/109 | 20.2 | 7/75 | 9.3 | 2.46 (0.99–6.09) | 0.052 |
| LABA + leukotriene | 28/58 | 48.3 | 10/33 | 30.3 | 2.15 (0.87–5.30) | 0.098 |
| LABA only | 19/36 | 52.8 | 18/37 | 48.7 | 1.18 (0.47–2.96) | 0.724 |
| No LABA | 31/376 | 8.2 | 29/476 | 6.1 | 1.39 (0.82–2.34) | 0.224 |
| All vs. no LABA | Comparison of ORs† |
0.668 | ||||
| All ICS | 31/243 | 12.8 | 12/241 | 5.0 | 2.79 (1.40–5.57) | 0.004* |
| LABA + ICS | LABA section |
|||||
| ICS only | 9/134 | 6.7 | 5/166 | 3.0 | 2.32 (0.76–7.09) | 0.140 |
| No ICS | 69/336 | 20.5 | 52/380 | 13.7 | 1.63 (1.10–2.42) | 0.015* |
| All vs. no ICS | Comparison of ORs† |
0.186 | ||||
| All leukotriene | 29/99 | 29.3 | 11/75 | 14.7 | 2.41 (1.11–5.22) | 0.026* |
| LABA + leukotriene | LABA section |
|||||
| Leukotriene only | 1/41 | 2.4 | 1/42 | 2.4 | 1.02 (0.06–16.95) | 0.986 |
| No leukotriene | 71/480 | 14.8 | 53/546 | 9.7 | 1.61 (1.11–2.36) | 0.013* |
| All vs. no leukotriene | Comparison of ORs† |
0.361 | ||||
| All short-acting β-agonist (only) | 3/63 | 4.8 | 4/86 | 4.7 | 1.02 (0.22–4.75) | 0.975 |
| No short-acting β-agonist | 97/516 | 18.8 | 60/535 | 11.2 | 1.83 (1.29–2.59) | <0.001* |
| All vs. no short-acting β-agonist | Comparison of ORs† |
0.469 | ||||
| All placebo (only) | 18/138 | 13.0 | 19/182 | 10.4 | 1.29 (0.65–2.56) | 0.471 |
| No placebo | 82/441 | 18.6 | 45/439 | 10.3 | 2.0 (1.35–2.96) | <0.001* |
| All vs. no placebo | Comparison of ORs† | 0.274 | ||||
Definition of abbreviations: CI = confidence interval; ICS = inhaled corticosteroid; LABA = long-acting β-agonist; OR = odds ratio.
Significant exacerbations for DICE, IMPACT, SMOG, and PRICE (which had no treatment failures) were counted as treatment failures.
*
P < 0.05, all P values and ORs from logistic regression.
†
Tests the significance of the difference in ORs in the age group between the therapy groups.