Figure 2.

The probability of severe sepsis readmission correlates with probable microbiome disruption during index hospitalization. This figure depicts adjusted probabilities of 90-day hospital readmission for severe sepsis (red) and nonsepsis diagnoses (blue) following live discharge from hospitalization without infection, hospitalization with non–Clostridium difficile infection, and hospitalization with C. difficile infection. Probabilities are adjusted for age, sex, race, ethnicity, education, total wealth, limitations of activities and instrumental activities of daily living, and 31 Elixhauser comorbidities. Adjusted probabilities of rehospitalization for nonsepsis diagnoses are not different following the three exposures, whereas rehospitalization for severe sepsis is incrementally greater after exposures with increasing probable microbiome disruption.