Figure 5. Different divergence rates between scorpion toxin-bound regions and non-bound regions of Na_v channels.

Three fixed-sites models (D–F) were used to calculate ω values for two partitions of the VSD in Na_v channels from birds, lizards, mammals and insects: one partition representing the scorpion toxin-bound regions (two extracellular loops, bars in light green) and the other the four transmembrane helices and the intracellular loop (bars in orange).