Table 1. Chemical structure, ligand lipophilicity efficiency (LLE), and pharmacological activity of compounds 7–32.

^aIC₅₀ values were measured if the inhibition rate at 10 μM was larger than 50%. ^bCompounds commercially obtained. ^cclogP values were calculated by Qikprop software⁶². ^dLLE values were calculated using the formula LLE = pIC₅₀ − clogP⁶³.